~ Excitable systems and pattern formation ~
| Agladze Laboratory, iCeMS, Kyoto Universty
~ Excitable systems and pattern formation ~ |
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| About the Laboratory
 Our highly diverse group of researchers includes biophysicists, chemists, biochemists, material scientists, as well as computational scientists, advancing the interdisciplinary field of physics and
bio-physics of excitable and self-organizing systems. Special attention is paid to the mechanisms of transition to a chaotic state in cardiac tissue, which might be lethally dangerous. Understanding how a heart can lose its orchestrated function allows for the development of efficient methods to fight cardiac arrhythmia. As a rule, the precursors of such a dangerous state in the heart muscle are rotating spiral waves or reentries. Currently, the following four directions of study are being developed:
1. Study of fundamental mechanisms of reentry (or spiral waves) originating in the heart based on the curvature-related failure of the propagating wave. 2. Development of a novel method for controlling cardiac activity based on reversible sensibilization of voltage-gated ion channels of cardiomyocytes to light and subsequent meso-scale changes in membrane-protein complexes responsible for cardiomyocytes functioning. 3. Development of nanofiber-based scaffolds for cardiac tissue engineering employing a meso-scale approach in investigation of single-cell and single-fiber attachment. These scaffolds will allow us to construct functional artificial cardiac tissue patches with well-controlled structures. 4. Study of interaction and common network formation of primary culture cardiomyocytes with cardiomyocytes descended from pluripotent cells, as a generic experimental model for cardiac tissue repair. ⇒Watch a presentation "How chemical waves could help us to heal? " by Professor Agladze (This presentation was done at the conference named "What is creativity ?") |